WebMar 14, 2024 · Abstract: PARP inhibitors (PARPi) are the maintenance therapy after first line platinum-based chemotherapy for patients with advanced epithelial ovarian cancer (EOC) with germline and pathogenic somatic BRCA1/2 mutations. However, as with chemotherapy, patients can develop resistance to PARPi. The selective pressure … Web2 days ago · Patients who completed and responded to first-line platinum-based chemotherapy with carboplatin or cisplatin were randomly assigned to receive oral senaparib at a starting dose of 100 mg, or ...
Rovalpituzumab Tesirine as a Maintenance Therapy After …
Web1 day ago · RAHWAY, N.J.--(BUSINESS WIRE)-- Merck (NYSE: MRK), known as MSD outside of the United States and Canada, today announced the U.S. Food and Drug Administration (FDA) has accepted for review a new supplemental Biologics License Application (sBLA) seeking approval for KEYTRUDA, Merck’s anti-PD-1 therapy, in … Web1 day ago · Pembrolizumab also received accelerated approval from the FDA in May 2024 for use in combination with trastuzumab (Herceptin), fluoropyrimidine- and platinum-containing chemotherapy, for the first ... dogfish tackle \u0026 marine
Uptake of Maintenance Immunotherapy and Changes in Upstream …
WebFirst-Line Chemotherapy. First line chemotherapy in advanced NSCLC usually consists of a combination of a platinum compound (cisplatin or carboplatin) with a third … WebJul 9, 2014 · Progression of tumour between start of first line platinum based chemotherapy for metastatic pancreas cancer and randomisation. Cytotoxic chemotherapy or non-hormonal targeted therapy within 28 days of Cycle. 1 Day 1 is not permitted. Exposure to an investigational product within 30 days or 5 half lives … WebSep 12, 2024 · Patients must have received at least 4 cycles, and a maximum of 6 cycles of second-line platinum-based chemotherapy. In patients with measurable disease, end of treatment scans must have a RECIST v1.1 'partial response' or 'complete response' and meet one of the following CA125 requirements: dog face on pajama bottoms