The SMR software tool was originally developed to implement the SMR & HEIDI methods to test for pleiotropic association between the expression level of a gene and a complex trait of interest using summary-level data from GWAS and expression quantitative trait loci (eQTL) studies ( Zhu et al. 2016 Nature Genetics ). WebJan 15, 2024 · The large amount of GWAS data available in the public domain provide a great opportunity for methods that are able to make inference about causality by integrating summary-level GWAS data from ...
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WebGWAS is listed in the World's largest and most authoritative dictionary database of … WebObservational studies and randomized controlled trials presented inconsistent findings on the effects of cholesterol-lowering statins on depression. It therefore remains unclear whether statins have any beneficial effects on depression, and if so, what the underlying molecular mechanisms are. templiner see bungalow
冠状动脉疾病相关变异对血管平滑肌细胞的影响 - 知乎
Web最近一项人类冠状动脉平滑肌细胞共定位研究报告了5个基因（SIPA1、TCF21、SMAD3、FES和PDGFRA），在eCAVIAR或SMR分析中显示出与CAD GWAS信号显著共定位。 在该研究中，其中三个基因（TCF21、SMAD3和FES）在eCAVIAR和SMR分析中均显示出显著共定位。 此外，在eCAVIAR或SMR分析中检测到81个基因（总共84个基因，包括TCF21 … WebSubsequently, we integrated the GWAS summary statistics derived from the testing set with the weights (or eQTLs) derived from the training set to identify expression-trait associations using (a) TWAS-MP (b) TWAS-SMR (c) eQTL-based GWAS, or (d) standalone GWAS. WebMar 28, 2016 · The results are from an SMR analysis of real GWAS data for five complex traits (Supplementary Table 6) and simulated eQTL data. … templiner kartbahn