Webb4 jan. 2024 · Inhibition of Zika virus replication by G-quadruplex-binding ligands Zika virus (ZIKV), a mosquito-transmitted Flavivirus, emerged in the last decade causing serious diseases and affecting human health globally. Currently, no licensed vaccines or antivirals are available to combat ZIKV, although several vaccine candidates are in the pipeline. Webb19 juni 2024 · c-Myc is a transcription factor that plays a crucial role in cellular homeostasis, and its deregulation is associated with highly aggressive and chemotherapy-resistant cancers. After binding with partner MAX, the c-Myc–MAX heterodimer regulates the expression of several genes, leading to an oncogenic phenotype. Although …
First-in-Human, First-in-Class Phase I Trial of the Anti-CD47 …
Webb1 feb. 2024 · The Myc G4 is a 27 bp sequence found in the nuclease hypersensitive element (NHE) III (1) region upstream of the Myc promoter, and is one of the most well-studied promoter G4s, with early reports showing its stabilization using a small molecule leading to inhibition of Myc expression in cells. 16 The Myc G4 is thought to form … Webb25 feb. 2024 · G4 structure formation can drive genome instability by creating mutations, deletions and stimulating recombination events. The importance of G4 structures in the … splice ear candy
Small-molecule G-quadruplex stabilizers reveal a novel pathway of ...
Webb23 feb. 2015 · ResponseFormat=WebMessageFormat.Json] In my controller to return back a simple poco I'm using a JsonResult as the return type, and creating the json with Json … Webb7 maj 2024 · Transcriptional inhibition by DRB or by triptolide reveals that promoter G4 formation, as assessed by G4 ChIP-seq, does not depend on transcriptional activity. … WebbIntroduction: G-quadurplex (G4) formation plays a role in many biological processes such as replication, transcription, translation and telomeric maintenance.Stabilization of G4 structure by peptide has recently emerged as a potential approach in the regulation of protein expression. In this study, we reported on regulation of cyan fluorescent protein … spliced varsity jacket