Ink4a/arffl/fl
WebbCell line name: PK4A: Accession: CVCL_WB21: Resource Identification Initiative: To cite this cell line use: PK4A (RRID:CVCL_WB21) Comments: Doubling time: ~24 hours … Webb21 feb. 2024 · We perform studies with p48-Cre;KrasG12D (KC), pdx1-Cre;KrasG12D ;Ink4a/Arffl/fl (KIC) and pdx1-Cre;KrasG12D ;p53R172H (KPC) and tumor tissues from PDAC and chronic pancreatitis patients. We also...
Ink4a/arffl/fl
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WebbContains a targeted mutation of Cdkn2a (Ink4a/Arf) which introduced LoxP sites upstream of exon 2 and downstream of exon 3.; Cross with the tissue-specific Cre of your choice to develop a tumor model; The cell cycle inhibitory protein Cdkn2a is frequently disrupted in various types of human cancer, and germline mutations of this locus can confer … Webb14 maj 2012 · Adult BrafV600Efl/+ Ink4a-Arffl/fl ... Ink4a-arf fl/fl (Fig. 1C). No tumor formation was observed following injections of Braf CA/+ mice for up to 490 d postinjection (Fig. 1D and Table 1). In contrast, intracranial …
Webb4 mars 2024 · Here we wanted to define, by using an microarray approach and the Pdx1-cre;LSL-KrasG12D;INK4a/arffl/fl, the pathways involved in muscle, liver and white … Webbgenotype: Pdx1-Cre; Ink4a/Arffl/fl; LSL-KrasG12D gender: Male age: 6 weeks-old: Treatment protocol: No treatment. Extracted molecule: total RNA: Extraction protocol: …
Webb19 nov. 2024 · Les changements métaboliques liés à la progression tumorale ont été caractérisés dans un modèle murin développant un ADKP (Pdx1-Cre; LSL-KrasG12D; Ink4a/Arffl/fl). Les voies lipidiques les plus augmentées aux stades intermédiaire et avancé de la maladie sont associées au métabolisme des éicosanoïdes, notamment la … Webb10 nov. 2024 · Design We performed studies with p48- Cre; KrasG12D , pdx1 -Cre; Kras G12D ;Ink4a / Arffl/fl , pdx1 -Cre; Kras G12D ; p53 R172H mice and tumour tissues from patients with pancreatic ductal ...
WebbHere we wanted to define, by using an microarray approach and the Pdx1‐cre;LSL‐KrasG12D;INK4a/arffl/fl mice model, the pathways involved in muscle, liver, and white adipose tissue wasting. These mice, which develop systematically pancreatic cancer, successfully reproduced many human symptoms afflicted with this disease, and …
WebbWe perform studies with p48-Cre;KrasG12D (KC), pdx1-Cre;KrasG12D ;Ink4a/Arffl/fl (KIC) and pdx1-Cre;KrasG12D ;p53R172H (KPC) and tumor tissues from PDAC and chronic pancreatitis patients. township of medford water and sewerWebbDOAJ is a community-curated online directory that indexes and provides access to high quality, open access, peer-reviewed journals. township of medford nj tax officeWebb10 jan. 2014 · Cancer cachexia syndrome is observed in 80% of patients with advanced-stage cancer, and it is one of the most frequent causes of death. Severe wasting accounts for more than 80% in patients with advanced pancreatic cancer. Here we wanted to define, by using an microarray approach and the Pdx1-cre;LSL-KrasG12D;INK4a/arffl/fl, the … township of medford tax collectorWebb16 feb. 2024 · These tumors are highly metastatic and we can model pulmonary metastasis using multiple tools already available in my lab including human UPS cells for xenograft, as well as two independent autochthonous genetic models (KrasG12D/+; Ink4a/Arffl/fl and KrasG12D/+; Trp53fl/fl (5)), and allografts of murine tumor cells derived from these … township of medford taxestownship of mendham nj tax collectorWebbIn this study, we generated pancreatic tumor cells derived from KIC mice (LSL-KRasG12D; Ink4a/Arffl/fl; Pdx1-Cre), lacking or not Ldlr (Ldlr-/- and Ldlr+/+ PK4A cells). We used fluorescent labelled-vector cargo conjugates targeting LDLR extracellular domain or -scramble conjugates (Fc (A680)-VH4127 and Fc (A680)-VH04sc, respectively). township of maywood njWebbThe unique INK4A/ARF locus at chromosome 9p21 encodes two distinct proteins that intimately link the pRB and p53 tumour suppressor pathways. p16INK4A has been … township of mendham nj