Irf3 transcription factor

Author: umnp

August undefined, 2024

IRF3 is a member of the interferon regulatory transcription factor (IRF) family. IRF3 was originally discovered as a homolog of IRF1 and IRF2. IRF3 has been further characterized and shown to contain several functional domains including a nuclear export signal, a DNA-binding domain, a C-terminal IRF association … See more Interferon regulatory factor 3, also known as IRF3, is an interferon regulatory factor. See more IRF3 has been shown to interact with IRF7. See more • Pitha PM, Au WC, Lowther W, Juang YT, Schafer SL, Burysek L, Hiscott J, Moore PA (1999). "Role of the interferon regulatory factors (IRFs) in virus-mediated signaling and regulation of cell growth" See more • Interferon+Regulatory+Factor-3 at the U.S. National Library of Medicine Medical Subject Headings (MeSH) • FactorBook IRF3 See more WebMay 31, 2024 · IRF3 (interferon regulatory factor 3) serves as an indispensable transcription factor for type I IFN production. After receiving upstream signals, IRF3 goes through diverse processes to activate the type I IFN signaling, including phosphorylation, dimerization, translocation to nucleus and stimulation of DNA binding and transcriptional activity ...

Virus-dependent phosphorylation of the IRF-3 transcription factor ...

WebIRF3 Transcription Factor Assay Kit (Colorimetric) (ab207210) is a high throughput assay to quantify IRF3 activation in nuclear extracts. This assay combines a quick ELISA format … WebJul 25, 2024 · The discovery Interferon-regulatory factor 3 (IRF3) and IRF7 are the two pivotal transcriptional factors that directly control the production of IFN-α and IFN-β, determining the antiviral... date first us covid case

A maturation defective HIV-1 activates cGAS

WebMar 9, 2024 · IRF3 is a major transcriptional regulator of adipose inflammation and is involved in maintaining systemic glucose and energy homeostasis Findings indicate that STING-TBK1-IRF3 pathway mediates a crosstalk between ER stress and apoptosis during M. bovis infection, which can effectively control intracellular bacteria. WebIRF-3 is expressed constitutively in a variety of tissues, and the relative levels of IRF-3 mRNA do not change in virus-infected or IFN-treated cells. Following virus infection, IRF-3 is … Web1 day ago · STING recruitment of TBK1 and IRF3 results in IRF3 phosphorylation by TBK1 and IRF3 55 nuclear translocation[18, 19]. Activated STING also activates IKK and the NF-κB family of 56 transcription factors[20], which with IRF3, activate expression of type I IFN and subsequently 57 ISGs. ISGs include an array of anti-HIV restriction factors ... date first written above

Frontiers Therapeutic Targeting of IRFs: Pathway-Dependence or ...

IRF3 - an overview ScienceDirect Topics

WebJun 19, 2012 · Given that IRF3 acts as a transcription activator for promoters of genes encoding type I interferons but not for the Il12b promoter, it will be useful to explore the molecular mechanism by... WebDec 4, 2024 · IRF3 and IRF5 are phosphorylated by protein kinases, which are activated by signalling pathways of pattern recognition receptors (PRRs), including Toll-like receptors (TLRs) that signal via TRIF (TLR3 and TLR4) and MyD88 (e.g. … bivariate research questionWebNov 1, 2012 · IRF3 and IRF7 have multiple sites that—upon viral infection—are substrates for phosphorylation by the serine/threonine kinases TANK-binding kinase 1 (TBK1) and IκB … bivariate relationship stats

"WebIRF3 → Interferon regulatory factor 3 (IRF-3) Gene name : IRF3 Family name : IRF Entry whose protein (s) existence is based on evidence at protein level. Show evidences Annotations in this section apply to all the isoforms if not specified otherwise. OVERVIEW " - Irf3 transcription factor

Irf3 transcription factor

Selective autophagy controls the stability of transcription factor IRF3 …

WebOct 15, 2024 · Using two model transcription factors, IRF3 and STAT1, we demonstrate that transcription factor dimerization enables the trans-autoacetylation of p300 in a highly … WebHowever, the mechanisms by which IRF3 causes ALD remain obscure.IRF3 is a constitutively expressed transcription factor that resides in the cytoplasm and dimerizes …

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WebIRF3 is a transcription factor which is a major regulator of the type I interferon (IFN) antiviral response after recognition of viral DNA or RNA by intracellular foreign nucleic acid sensors, such as Toll-like receptors (TLRs), retinoic acid-inducible gene I (RIG-I), and cyclic GMP-AMP synthase (cGAS) (reviewed in [10]). IRF3 activa- WebPreviously, it was shown that IRF3 is a downstream transcription factor that regulates the expression of IFNβ induced by TRIF-dependent TLRs 28, 29. ... 22, via the inhibition of NLRP1 and NLRP3 inflammasome, or via induction of IL-10 who then through activation of STAT3 transcription factor reduced the abundance of pro-IL-1a and pro-IL-1β.

WebMay 27, 2024 · Thereafter, TBK1 in this signalosome phosphorylates C-terminus of interferon regulatory factors 3 (IRF3), which mobilizes IRF3 for dimerization and nuclear translocation, where it functions as transcription factor to induce the expressions of type I interferons (IFN-Is), various cytokines, and subsequently a multitude of IFN-stimulated … WebUsing cellular and mouse models, we reveal IRF3, a critical component of innate antiviral immunity, inhibits the activity of NF-κB, the pro-inflammatory transcription factor. Mechanistically, IRF3 binds the NF-κB–p65 subunit and prevents its …

WebMar 29, 2024 · IRF3 is activated by phosphorylation (by kinases TBK1 and IKKε), promoting dimerization, nuclear translocation, association with the co-activator CREB-binding protein … WebThe interferon regulatory factors (IRF) consist of a growing family of related transcription proteins first identified as regulators of the alpha beta interferon (IFN-alpha/beta) gene promoters, as well as the interferon-stimulated response element (ISRE) of some IFN-stimulated genes. IRF-3 was orig …

WebThe infection of mammalian cells by viruses and innate immune responses to infection are spatiotemporally organized processes. Cytosolic RNA sensors trigger nuclear …

WebThe downstream signaling pathways from PRR activation phosphorylate ubiquitously expressed IRFs (IRF1, IRF3, and IRF7) through IRF kinases, such as TANK-binding kinase 1 … date first reach south poleWebSince STAT2 inhibits the transcription of IRF3-dependent, but not NF-kB–dependent genes, STAT2 may impair the ability of TBK1 to phosphorylate IRF3 by disrupting the IRF3–STING interaction. On the other hand, STAT2 has a strong nuclear export signal when Y690 is not phosphorylated ( 50 ). datefirst smartphoneWebThe transcription factor IFN regulatory factor 3 (IRF3) plays an essential role in this process (3, 4). It was also reported that IRF3 is required to protect the host from viral infections, … bivariate relationshipWebSep 19, 2013 · IRF3 is a constitutively expressed transcription factor that resides in the cytoplasm and dimerizes and translocates to the nucleus upon phosphorylation ().Phosphorylated IRF3 induces IFN-β during viral infection, but may also contribute to inflammatory cytokine response to LPS ().IRF3 also promotes apoptosis in virus-infected … bivariate regression exampleWebApr 14, 2003 · The transcription factors interferon regulatory factor 3 (IRF3) and NF-κB are required for the expression of many genes involved in the innate immune response. Viral infection, or the binding of ... bivariate response surface analysisWebIRF3 is a transcription factor that controls multiple IFN-inducing pathways, including the TLR3 pathway, which can be triggered by dsRNA, and the pathways triggered by other … date fit officialWebApr 11, 2024 · TLR signaling cascades typically converge on transcription factors such as NFκB, AP-1, and IRF3 that initiate the synthesis of a battery of innate immune effectors involved in antibacterial ... bivariates analyseverfahren