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WebAim: Severe cardiac toxicity of doxorubicin and an immunosuppressive tumor micro-environment become main obstacles for the effective treatment of B-cell lymphoma. In this research, rituximab-conjugated and doxorubicin-loaded microbubbles (RDMs) were designed for exploring a combination approach of targeted microbubbles with ultrasound … WebMethotrexate and its long-acting polyglutamate metabolites also exert anti-inflammatory effects by releasing the endogenous autocoid adenosine. 3 As potent inhibitors of the enzyme 5-aminoimidazole-4-carboxamide ribonucleotide (AICAR) transformylase, methotrexate polyglutamates promote the accumulation of AICAR in tissues. Since … sea view beach resort lindi
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