WebThe Outcomes of a Prospective Trial of Intravenous Milrinone for Exacerbations of Chronic Heart Failure (OPTIME-CHF) study randomized 949 patients with systolic dysfunction and decompensated HF to receive 48 to 72 h of intravenous milrinone or placebo. The primary end point was days hospitalized from cardiovascular causes within 60 days. WebThe study design 12 and primary results of OPTIME-CHF have been published previously. 13 OPTIME-CHF randomized 949 patients with systolic dysfunction and worsening heart failure to receive 48 to 72 hours of intravenous milrinone (0.5 μg kg −1 min −1 without a loading dose) or placebo in a double-blinded fashion.
Congestive Heart Failure - StatPearls - NCBI Bookshelf
Webtime observed in the OPTIME–CHF trial, future trials investigating treatments for patients admitted with wors-ening CHF can evaluate efficacy end-points in a smaller number of patients than those typically required for outpatient CHF trials. (7 ) In the OPTIME–CHF trial w4 x patients admitted for worsening CHF had a higher incidence of diabetes WebNov 7, 2024 · Introduction Heart failure is a common and highly clinical syndrome that results from any functional or structural heart disorder, impairing ventricles filling or ejection of blood to of systemic circulation to meet the body's needs. Heart failure can be caused by several different diseases. balkan bakery la grange
Rationale and design of the OPTIME CHF trial: Outcomes of a …
WebThe study design 12 and primary results of OPTIME-CHF have been published previously. 13 OPTIME-CHF randomized 949 patients with systolic dysfunction and worsening heart failure to receive 48 to 72 hours of intravenous milrinone (0.5 μg kg −1 min −1 without a loading dose) or placebo in a double-blinded fashion. WebMar 19, 2003 · Heart failure etiology and response to milrinone in decompensated heart failure: results from the OPTIME-CHF study. Milrinone may have a bidirectional effect based on etiology in decompensated HF. Milrinone may be deleterious in ischemic HF, but neutral to beneficial in nonischemic cardiomyopathy. WebNov 7, 2024 · The Outcomes of a Prospective Trial of Intravenous Milrinone for Exacerbations of Chronic Heart Failure (OPTIME-CHF) trial demonstrated a significantly increased risk of in-hospital mortality as well as 30-day mortality in patients with HF who presented with hyponatremia. The mean serum sodium for patients enrolled in the study … balkan austin