2024 Pulmonary ionocyte

Pulmonary ionocyte

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August undefined, 2024

WebMay 13, 2024 · The aptitude of pulmonary resident stem/progenitor cell populations to restore lung homeostasis and the success and promise of adoptive cell therapy in immune disorders’ treatment inspire researchers to probe into ... A single-cell atlas of the airway epithelium reveals the CFTR-rich pulmonary ionocyte. Nature. 2024;560:377 ... WebAug 3, 2024 · 研究人员将它们命名为“肺离子细胞（ pulmonary ionocyte ）”，因为它们的基因表达模式有点类似离子细胞，过去，这类细胞被认为是专门负责调节鱼类腮和蛙类皮肤中离子迁移和水合作用的。. 令人意外的是，小鼠和人类组织中这类细胞表达的CFTR基因比其他任 …

Moshe Biton - Principal Investigator - Weizmann Institute of

WebSep 2, 2024 · Discoveries from both of teams, point to new strategies for treating cystic fibrosis, such as increasing the amount of pulmonary ionocytes to increase the amount of … WebNov 21, 2024 · Mucus secretion and mucociliary transport are essential defense mechanisms of the airways. Deviations in mucus composition and secretion can impede mucociliary transport and elicit airway obstruction. As such, mucus abnormalities are hallmark features of many respiratory diseases, including asthma, cystic fibrosis and … toyota nalley roswell

A single-cell atlas of the airway epithelium reveals the CFTR-rich ...

WebAug 2, 2024 · But the researchers found that this new pulmonary ionocyte has exceptionally high levels of CFTR expression, meaning that these cells - if mutated - could be causing … WebAug 1, 2024 · A single-cell atlas of the airway epithelium reveals the CFTR-rich pulmonary ionocyte. Nature, 2024; DOI: 10.1038/s41586-018-0394-6; WebAug 3, 2024 · Scientists have discovered a new type of cell in the human respiratory tract called the pulmonary ionocyte, and linked it to lung function decline in cystic fibrosis. … toyota namc acronym

Discovering Rare Cell Types with Single Cell RNA-Seq

WebAug 1, 2024 · When the cystic fibrosis gene from 1989 – dubbed CFTR – is active, it is usually in the pulmonary ionocyte, which makes up just 1-2% of the airway. The team … WebA single-cell atlas of the airway epithelium reveals the CFTR-rich pulmonary ionocyte. Lindsey W. Plasschaert 1,5,7, Rapolas Žilionis 2,3,7, Rayman Choo-Wing 1,5, Virginia … toyota nash texasWebOct 24, 2024 · The discovery of the "pulmonary ionocyte" demonstrates how identifying new cell types can be immediately useful to disease research. When a team at Massachusetts … toyota nascar sweepstakes

"WebNovel technology for gene expression analysis, such as single cell RNA sequencing (scRNA-Seq), has identified previously unknown cell types in the airway epithelium, as shown by … " - Pulmonary ionocyte

Pulmonary ionocyte

Web开馆时间：周一至周日7:00-22:30 周五 7:00-12:00; 我的图书馆 WebAug 1, 2024 · Finally, we identified a novel, rare cell type that we call the ‘pulmonary ionocyte’, which co-expresses FOXI1, multiple subunits of the vacuolar-type H+-ATPase (V …

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WebApr 7, 2024 · The ionocyte homeostasis and regeneration are regulated by cftr, and its mutations cause osmotic imbalance and modified mucus properties, leading to cystic fibrosis (9, 11). While cftr expression was missing in our single-cell dataset, we reconfirmed its patched expression in foxi1+ ionocytes using bulk transcriptomics data and in situ …

WebAug 1, 2024 · They also described several new cell types, including one that the team has named the pulmonary ionocyte, after salt-regulating cells in fish and amphibian skin. These lung cells express similar genes as fish and amphibian ionocytes, the team found, including a gene coding for the transcription factor Foxi1, which regulates genes that play a role in … WebAug 6, 2024 · Investigators from the Broad Institute of MIT and Harvard and Massachusetts General Hospital (MGH) have discovered a rare cell type in airway tissue that appears to …

WebUsing immunofluorescence, signaling pathway modulation, and electrophysiology, we show that Notch signaling is necessary and FOXI1 expression sufficient to drive the production … Web主营产品：elisa试剂盒厂家,人elisa试剂盒批发,大鼠elisa试剂盒批发,小鼠elisa试剂盒厂家,生化法检测试剂盒、分子学检测试剂盒研发生产销售,并经营各大进口原装品牌、国产抗体抗原,细胞菌株,生物培养基,生物化学试剂,实验耗材等生物科研产品,并提供实验外...

An ionocyte (formerly called a chloride cell) is a mitochondrion-rich cell within ionoregulatory organs of animals, such as teleost fish gill, insect Malpighian tubules, crustacean gills, antennal glands and maxillary glands, and copepod Crusalis organs. These cells contribute to the maintenance of … See more Marine teleost fishes consume large quantities of seawater to reduce osmotic dehydration. The excess of ions absorbed from seawater is pumped out of the teleost fishes via the ionocytes. These cells use active … See more • Pulmonary ionocyte - a rare type of specialised cell that may regulate mucus viscosity in humans See more • Zadunaisky JA (June 1996). "Chloride cells and osmoregulation". Kidney International. 49 (6): 1563–7. doi:10.1038/ki.1996.225. PMID 8743455. See more

WebAug 1, 2024 · Fig. 5: The pulmonary ionocyte is a novel mouse and human airway epithelial cell type that specifically expresses CFTR. a, Mouse pulmonary ionocyte markers. … toyota n30 hilux 4x4 pickup truckWebAug 1, 2024 · The team dubbed this cell the “pulmonary ionocyte” because its gene expression pattern was similar to ionocytes — specialized cells that regulate ion transport … toyota name originWebMar 1, 2024 · The identification and characterization of the pulmonary ionocyte raises intriguing new possibilities for CF therapy. Identifying the signaling pathways that drive … toyota natchez service departmentWeb这两个课题组均通过单细胞RNA测序技术在人和鼠的呼吸道上皮细胞中发现了一种新型肺细胞——“ 肺部离子细胞 ” (pulmonary ionocyte)，这种新型肺细胞共表达FOXI1以及H+分泌的V … toyota nash txWebJul 25, 2024 · Title. A single cell atlas of the airway epithelium reveals the CFTR-rich pulmonary ionocyte. Organisms. Homo sapiens; Mus musculus. Experiment type. … toyota naples germainWebpulmonary ionocyte : a possible key to cystic fibrosis Proinfinityclasses.com August 29, 2024 Cystic Fibrosis is a progressive, genetic disease that causes persistent lung … toyota nation avalon forumWebUsing immunofluorescence, modulation of signalling pathways and electrophysiology, we show that Notch signalling is necessary and FOXI1 expression is sufficient to drive the … toyota nashua nh dealership