2024 Terfenadine and ketoconazole

Terfenadine and ketoconazole

Author: pcjx

August undefined, 2024

WebThe findings suggest that intraconazole in therapeutic doses inhibits terfenadine metabolism. It is also possible that unmetabolised terfenadine alone, without an increased level of its active metabolite, may cause torsades de pointes. The concomitant use of terfenadine and itraconazole (and ketoconazole) should be avoided. WebKetoconazole can increase the concentrations of astemizole and terfenadine by inhibition of CYP3A4. High concentrations of terfenadine can cause cardiac toxicity. Increased plasma concentrations of unmetabolized terfenadine prolong the QT interval and carry the risk of torsade de pointes and other fatal ventricular arrhythmias (13).

Second-generation antihistamines : A comparative review

WebTerfenadine and ketoconazole are the most widely used positive reference agents in non-clinical cardiac repolarization safety stud-ies. The aim of the present study was to evaluate the effects of ... WebIn this patient, administration of magnesium sulfate may explain the absence of recurrence. The arrhythmia was most probably due to the combination of itraconazole and terfenadine as torsades de pointes have been described during … razboi ucraina protv

POSSIBLE DANGEROUS INTERACTION BETWEEN TERFENADINE AND KETOCONAZOLE.

Web15 Dec 2006 · Similarly, ketoconazole and telithromycin administered alone resulted in a mean increase in the QTc interval of 6.4 ms and 3.3 ms, respectively . However, when administered concurrently, telithromycin exposures significantly increased (95% increase in area under the curve from 0–24 h), resulting in a mean increase in the QTc interval of … Web31 Dec 1998 · Abstract: Terfenadine is a nonsedating H1-antagonist that when overdosed, used with hepatic compromise, or when given with ketoconazole results in accumulation of parent terfenadine, prolongation of the QT interval, and torsades de pointes in susceptible patients. Nine subjects were given the recommended dose of terfenadine (60 mg every 12 … Web1 Jul 2010 · Terfenadine and ketoconazole are the most widely used positive reference agents in non-clinical cardiac repolarization safety studies. The aim of the present study … @ds_macro_skull

Evaluation of terfenadine and ketoconazole- induced QT …

Terfenadine - an overview ScienceDirect Topics

Web5 Nov 2015 · 世界*实验材料供应商BD genetest 正式授权上海起发为其中国代理，BD genetest 在一直是行业的*,一直为广大科研客户提供zui为优质的产品和服务,上海起发一直秉承为中国科研客户带来的产品，的服务，签约BD genetest 就是为了给广大科研客户带来更加完善的产品和服务,您的满意将是我们zui大的收获 WebTéléchargez notre application gratuite. Traduction Context Correcteur Synonymes Conjugaison Documents Dictionnaire Dictionnaire Collaboratif Grammaire Expressio Reverso Corporate Plus razboi ucraina hartaWeb11 Dec 1990 · The most likely precipitant of this effect was ketoconazole, an agent that inhibits the cytochrome P-450 oxidative pathway that is presumed to be involved in terfenadine metabolism. The authors warn that other drugs affecting P-450 metabolism, including cimetidine and erythromycin, may also interact with terfenadine. dsm agoraphobie

"WebTerfenadine was withdrawn from the U.S. market in 1998. Do not take terfenadine with any of the following medicines: the antifungal drugs ketoconazole (Nizoral) or itraconazole (Sporanox); the antibiotics erythromycin (E.E.S., E-Mycin, Ery-Tab), clarithromycin (Biaxin), or azithromycin (Zithromax); or the ulcer drug cimetidine (Tagamet, Tagamet HB). " - Terfenadine and ketoconazole

Terfenadine and ketoconazole

Ketoconazole potentiates terfenadine-induced apoptosis …

Web24 Dec 2001 · For example, coadministration of ketoconazole with terfenadine has been associated with altered cardiac repolarization leading to QTc interval prolongation and torsades de pointes . Similarly, ventricular dysrhythmias and torsades de pointes have been reported with astemizole, usually with overdosage. Web1 Mar 1993 · Ketoconazole alters the metabolism of terfenadine in normal men and women and results in the accumulation of unmetabolized parent drug, which is associated with …

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WebIn treatment 2 (T2) we examined the effect of oral pretreatment with ketoconazole (200 mg daily for 5 days) on the same absorption parameters. Each experiment was divided into … WebKetoconazole alters the metabolism of terfenadine in normal men and women and results in the accumulation of unmetabolized parent drug, which is associated with significant prolongation of the corrected QT interval and should be avoided. OBJECTIVE To examine prospectively the effects of ketoconazole on the pharmacokinetics and …

Web1 Jul 1992 · Torsades de Pointes after treatment with terfenadine and ketoconazole European Heart Journal Oxford Academic Abstract. An episode of QT prolongation with symptomatic Torsades de Pointes is described which developed in a 22-year-old healthy female following 5 days thera Web30 Nov 1993 · Conclusions. —Ketoconazole alters the metabolism of terfenadine in normal men and women and results in the accumulation of unmetabolized parent drug, which is associated with significant prolongation of the corrected QT interval. This drug combination should be avoided. (JAMA. 1993;269:1513-1518)...

Web2 Apr 1993 · The nonsedating antihistamine terfenadine has been linked to torsades de pointes, a cardiac arrhythmia, particularly when prescribed with ketoconazole. Two … WebTerjemahan frasa EVIDENCE OF INTERACTION dari bahasa inggris ke bahasa indonesia dan contoh penggunaan "EVIDENCE OF INTERACTION" dalam kalimat dengan terjemahannya: There is no evidence of interaction between the two nations prior...

Web1 Jul 2010 · Terfenadine and ketoconazole are the most widely used positive reference agents in non-clinical cardiac repolarization safety studies. The aim of the present study …

Webterfenadine (50 mg/kg), ketoconazole (200 mg/kg) or a combination of terfenadine and ketoconazole. Recording and analysis of waveforms The ECG waveforms were recorded … razboi ucraina prima ziWeb1 Dec 2013 · As ketoconazole needs acid for its absorption, antacids, H2 antagonists (cimetidine, famotidine, ranitidine) and omeprazole should not be taken for 2 hours after … dsmajuWebTerfenadine not only differs from the other antihistamine drugs in its chemical structure, but also in that its action begins within 1–2 h and last approximately 12 h, reaching its peak of action in 3–4 h. dsm 918 snWeb2 Apr 1993 · The nonsedating antihistamine terfenadine has been linked to torsades de pointes, a cardiac arrhythmia, particularly when prescribed with ketoconazole. Two studies evaluated this potential drug interaction. In the first, investigators gave oral terfenadine (60 mg twice daily) to six healthy volunteers for 7 days. dsm alaska loginWebTerfenadine is normally metabolized by CYP3A4 to fexofenadine, which has negligible cardiac effects. Atorvastatin is also a CYP3A4 substrate, and its effects on the … razbojisteWebDOI: 10.1016/S1734-1140(10)70325-X Corpus ID: 4756810; Evaluation of terfenadine and ketoconazole-induced QT prolongation in conscious telemetered guinea pigs. @article{Rajput2010EvaluationOT, title={Evaluation of terfenadine and ketoconazole-induced QT prolongation in conscious telemetered guinea pigs.}, author={Satyendra K. … d s malik c++ programmingWebOn sait depuis longtemps que, par interaction ou lors d' un surdosage, la terfénadine peut provoquer des troubles du rythme cardiaque, notamment des torsades de pointes pouvant avoir une issue fatale [voir Folia de septembre 1995, d’avril 1997]. Suite à une réévaluation récente, le Comité des Spécialités Pharmaceutiques (CSP) de l ... dsma logo