The sox2 transcription factor binds rna
WebApr 14, 2024 · SOX2 can bind directly to ES2 lncRNA with high affinity through its DNA-binding HMG domain [144]. Numerous studies have reported aberrant expression of SOX2 … WebFeb 4, 2024 · Some transcription factors that specifically bind double-stranded DNA appear to also function as RNA-binding proteins. Here, we demonstrate that the transcription factor Sox2 is able to directly ...
The sox2 transcription factor binds rna
Did you know?
WebJul 21, 2024 · ABSTRACT. The transcription factor SOX2 is a vital regulator of stem cell activity in various developing and adult tissues. Mounting evidence has demonstrated the … WebNov 23, 2015 · NANOG is a transcription factor that occupies single-copy loci, as well as TEs including the ERV1 repeat family and LTR7 sequences in pluripotent stem cells 14, 24. We observed that HPAT2,...
WebSeveral recent studies have revealed that the Sox2 transcription factor binds RNA through its high-mobility group box (HMGB) domain in vitro and in vivo. A high degree of … WebJul 24, 2013 · The transcription factor SRY (sex-determining region)-box 2 (SOX2) is an important functional marker of neural precursor cells (NPCs) and plays a critical role in self-renewal and neuronal differentiation; however, the molecular mechanisms underlying its functions are poorly understood.
WebFinally, while most SPFs induce TET-dependent active DNA demethylation, SOX2 binding leads to passive demethylation, an activity enhanced by the co-binding of OCT4. This finding suggests that... WebSox2 (SRY-box containing gene 2) lies at the center of these programs (Avilion et al., 2003; Takahashi and Yamanaka, 2006). Sox2 binds to DNA via its highly conserved HMG-box domain, often in co-operation with other transcription factors …
WebJan 10, 2024 · Transcription factors (TFs) interact with several other proteins in the process of transcriptional regulation. Here, we identify 6703 and 1536 protein–protein interactions …
WebAug 8, 2014 · Background The transcription factor, Sox2, is central to the behaviour of neural stem cells. It is also one of the key embryonic stem cell factors that, when overexpressed can convert somatic cells into induced pluripotent cells. Although generally studied as a transcriptional activator, recent evidence suggests that it might also repress … make 7 crossword clueWebJan 1, 2003 · The transcription factor SOX2 has also been implicated in the regulation of Fgf4 expression. We have used gene targeting to inactivate Sox2, examining the phenotypic consequences in mutant embryos and in chimeras in which the epiblast is rescued with wild-type ES cells. We find a cell-autonomous requirement for the gene in both epiblast and ... make 60hz smootherWebMar 13, 2024 · We report the unprecedented finding that the conserved RNA-binding motif protein, RBM24, positively controls Sox2 mRNA stability and is necessary for optimal SOX2 mRNA and protein levels in development, perturbation of which causes ocular defects, including microphthalmia and anophthalmia. make 6 with 3 identical digitsWebNov 26, 2024 · SRY-box transcription factor 2 (SOX2) overlapping transcript (SOX2-OT) is an evolutionarily conserved long noncoding RNA. Its intronic region contains the SOX2 gene, the major regulator of the pluripotency of embryonic stem cells. The human SOX2-OT gene comprises multiple exons and has multiple tran … make 6 figures working for yourselfWebSox2 is a member of the Sox family of transcription factors, which have been shown to play key roles in many stages of mammalian development. This protein family shares highly … make 64gb usb bootablemake717 innovation centerWebDownloadable! Certain transcription factors are proposed to form functional interactions with RNA to facilitate proper regulation of gene expression. Sox2, a transcription factor … make 7 for computer